Rhine, Main & Moselle Itineraries

With a wealth of fascinating destinations to visit along the Rhine, Main and Moselle rivers, we have specially curated a variety of unique 7-to-14-night itineraries for you to choose from in every delightful season.

Pictured: Brussels, Belgium

NEW IN 2025: 14-night Grand Rhine & Dutch Canals

Take in the architecture and artistry of castles such as Brussels’ Gaasbeek and Ghent’s Castle of the Counts before gliding past more than 40 fairytale castles in the Rhine Gorge on one immersive sailing! Enjoy your entire 14-night Grand River Cruise on board the same beautiful ship as you experience the best of Holland, Belgium, and the Rhine River.

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Pictured: Berkanstel, Germany

Captivating Rhine

Contoured by vineyard-clad hills and castles from yesteryear, the legendary Rhine captivates. Fabled towns lost in time present you with the chance to taste local flavors—Rüdesheimer coffee and Kölsch beer—and to touch history up close with guided hikes and bike rides. From Amsterdam’s colorful canals to the majestic Swiss Alps, journey into the heart of the destinations you visit.

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Pictured: Strasbourg, France

Christmas Markets on the Rhine

Experience the deep-rooted holiday traditions of Europe at its most festive time of year and get caught up in the magic of the holidays with visits to some of the world’s most timeless Christmas Markets. Warm up with a mug of steamy glühwein while at the Cologne Christmas Market located in front of its UNESCO-designated Gothic cathedral. Cherish all the glory of the season in grand European style as you cruise along the Rhine.

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Pictured: Cologne, Germany

Enchanting Rhine

Grand cities blend in perfect harmony with their historic past and their progressive future. Take a front-row seat on an enchanting journey that takes you along the Rhine and through its designated UNESCO World Heritage Site with its 40 castles strung like pearls on its river banks and to magnificent cities and charming villages alike.

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Pictured: Cochem Castle

Europe’s Rivers & Castles

From the meandering Main to the UNESCO-designated Upper Middle Rhine Valley with its multitude of castles dotting its shores to the vineyard-clad hills of the Moselle, enjoy Europe at its most picturesque. All along the way, gain an intimate understanding of the history and culture of the places you visit.

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Pictured: Rhine Gorge

Medieval Treasures

Walk through thousands of years of history in the medieval towns of Rothenburg, Bamberg and Miltenberg. Revel in the architectural gems on display and discover the Alsatian capital of France, Strasbourg and savor local flavors like rich Rüdesheimer coffee and hearty Bamberg smoked beer. All this and more awaits you as you experience the many medieval treasures of Europe.

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Pictured: Cochem, Germany

Rhine & Moselle Splendors

Expand your imagination in fairytale villages with medeival Market Squares and half-timbered houses where folklore and history come alive in every street. Blend German heritage with Italian in Trier, with its Roman Imperial Baths and the Porta Nigra; and with French heritage in Strasbourg, and you have the most splendid journey.

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Pictured: Heidelberg, Germany

Rhine & Moselle Delights

Dramatic rivers yielding to fairytale towns and iconic cities all come alive as you discover four countries along the storied Rhine and Moselle. Grand Baroque palaces, whimsical gardens and a plethora of UNESCO World Heritage Sites, provide lovers of enchantment, artists and architectures, historians and connoisseurs of fine wine, beer and food with the best these regions offer.

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Pictured: Berkanstel Castle

Rhine & Moselle Fairytales

Pages from fairytales come to life as you find inspiration along the fabled, castle-laden Rhine and its breathtaking tributary, the Moselle, with fascinating scenery of Europe’s steepest vineyards lining its shores. Colorful canals and glistening lakes, hilltop towns and majestic alps, mighty fortresses and storied castles, and hearty beer and delicate wines can all be experienced on this fairytale journey through time.

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Pictured: Basel, Switzerland

Rhine Castles & Swiss Alps

Embark on an unforgettable Rhine River cruise between picturesque Amsterdam, Netherlands and dynamic Basel, Switzerland. Along the way, you will explore charming villages and historic cities such as Cologne, Rüdesheim and Heidelberg. Cruise through the UNESCO-designated Rhine Gorge adorned with 40 castles and marvel at the breathtaking beauty of the Notre Dame Cathedral in Strasbourg.

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Pictured: Lahnstein, Germany

Swiss Alps & Rhine Castles

Cruise through the Netherlands, Germany, France and Switzerland from Basel to Amsterdam, visiting iconic landmarks and enjoying the majestic landscapes along the Rhine River. Highlights include the spectacular Rhine Gorge, where 40 castles sit upon the hillsides like crown jewels; the history and architecture on display throughout Cologne; and an evening tour of Lahnstein’s Lahneck Castle exclusively for AmaWaterways guests.

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Pictured: Rüdesheim Niederwald Monument

Treasures of the Main & Rhine

From Prague, the “City of Spires,” to the heartland of Germany along the Rhine and Main rivers and to cosmopolitan Amsterdam, you’ll get an up-close look at the magnificent castles, medieval towns and forever-inspiring cities. Savor the storybook atmosphere of some of Europe’s most charming towns and along the way, get swept up in the many treasures just waiting to be discovered along the Rhine and Main rivers.

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Pictured: Moselle Loop

Vineyards of the Rhine & Moselle

Drink in the beauty, history and flavor of the Rhine and Moselle river valleys’ iconic vineyards. Begin your journey with a gentle ride through Amsterdam’s legendary canals, and whet your palate for the wines ahead by tasting Kolsch beer. As for the vineyards, you’ll soar above them by gondola or hike among the grapes in Rüdesheim. Whatever you choose to do ashore, the stories you’re told and flavors that grace your palate will surely transform you.

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Unforgettable Land Packages

Our Rhine, Main & Moselle river journeys are best reserved with optional land packages before or after your sailing, accompanied by our wonderful Cruise Managers. Stay at recognized four and five-star hotels, plus enjoy convenient transfers between your hotel and ship, as well as a range of included amenities and excursions.

Explore more of these fascinating cities on select Rhine, Main & Moselle river cruises:

Pictured: Lake Como, Italy